Topics on COX-2 inhibitor.

COX-2 inhibitor.

he developed severe psoriasis responsive only to repeated courses of the then newly available PUVA (psoralen plus UVA radiation) therapy. Between 1973 and 1993 he received PUVA once a week. During treatment no genital protection was used although he had never received UV therapy directly to the genital area. Two years after the onset of psoriasis he developed peripheral inflammatory arthritis. ...

Cox-2 Inhibitor and an Antineoplasticagent

Antimicrobial Activity of Cox-2 Inhibitor

The present study was undertaken to evaluate the antimicrobial activity of Etoricoxib. At various concentrations, ranging from 20-100 μg/ml, Etoricoxib exhibits zone of inhibition of 6.5, 7, 8 and 13 respectively against p. aeruginosa while, it showed zone of inhibition of 10, 15, 18 against S. aureus and 8, 15 21 against E.coli at the concentration range of 25-100 μg/ml. It showed more activit...

Selective COX-2 inhibitor celecoxib prevents experimental autoimmune encephalomyelitis through COX-2-independent pathway.

Cyclooxygenase (COX) is a key enzyme of arachidonic acid metabolism and exists as two distinct isoforms. COX-1 is constitutively expressed in most tissues, whereas COX-2 is inducibly expressed at the site of inflammation. Selective inhibitors of COX-2 have been developed and have been used as anti-inflammatory agents. Here, we show that a new-generation COX-2 inhibitor, celecoxib, inhibited exp...

Growth stimulation of COX-2-negative pancreatic cancer by a selective COX-2 inhibitor.

Cyclooxygenase 2 (COX-2) inhibitors are promising antiangiogenic agents in several preclinical models. The aim of the present study was to evaluate the effect of selective COX-2 inhibitors on vascular endothelial growth factor (VEGF) production in vitro and angiogenesis and growth of pancreatic cancer in vivo, focusing on putative differences between COX-2-negative and COX-2-positive tumors. VE...